The 23-year-old missed out in 2012 as he competed for Great Britain at the London Olympics, winning a bronze medal in the men’s eight competition.
But he will stroke the Dark Blues in the 161st Boat Race as Oxford aim for a sixth success in eight years and their 11th since the turn of the century.
“I feel quite relaxed,” Louloudis told BBC Sport. “We’ve got a great bunch of guys and a good coaching staff so we’ve every reason to be confident.”
Oxford’s recent dominance also extends to the women’s event.
They have won six of the last seven stagings over a straight, 2,000m course, including last year’s race at Henley-on-Thames.
However, they had to be rescued by a lifeboat last week after getting into difficulties while training in the choppy waters of the Thames.
Their crew will be almost a kilo per rower lighter than that of Cambridge on Saturday as they race an hour before the men.
“The girls deserve it,” said the president of the Cambridge men, Alex Leichter. “They are working just as hard as we do for the same goal.
“It’s a good thing for the men’s team. It’s nice for our egos to get attention but it can also distract us. To some extent the girls are taking the pressure off us.”